Helios Airways Flight 522 · Greece

On August 14, 2005, Helios Airways Flight 522 (Greece). 121 people died.

From the Wikipedia article; it may show the aircraft rather than the accident. File page · Mila Daniel, CC BY-SA 4.0
Date
August 14, 2005
Place
Greece
Operator
Helios Airways
Killed
121
Position
38.231°N, 23.971°E
Wikidata ID
Q865513

From Wikipedia

Helios Airways Flight 522 was a scheduled international passenger flight from Larnaca, Cyprus, to Prague, Czech Republic, with a stopover in Athens, Greece, operated by a Boeing 737-300. Shortly after takeoff on 14 August 2005, Nicosia air traffic control (ATC) lost contact with the pilots operating the flight; it eventually crashed near Grammatiko, Greece. All 121 passengers and crew on board were killed. It is the deadliest aviation accident in Greek history.

An investigation into the accident by Greece's Air Accident Investigation and Aviation Safety Board (AAIASB) concluded that the crew had failed to notice that the cabin pressurization system was set to "manual" during takeoff checks. A ground engineer had set it to "manual" to conduct testing before the flight, but had most likely forgotten to restore it to "auto" afterward. This configuration was subsequently missed by the crew during their pre-flight checks. This caused the plane to gradually depressurize as it climbed, and resulted in everyone on board suffering from critical hypoxia.

Text from Wikipedia, “Helios Airways Flight 522”, CC BY-SA 4.0; shortened to the introduction. Authors.

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